Protein Details: Voltage-gated Potassium channel-interacting protein 2

Protein ID

ICDB_Pro_1584

Protein Name

Voltage-gated Potassium channel-interacting protein 2

Gene Name

KCNIP2; KCHIP2

Organism

Homo sapiens (Human)

Length

270 amino acids

AlphaFoldDB

AF-Q9NS61-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density;inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro;modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity)

Sequence

MRGQGRKESLSDSRDLDGSYDQLTGHPPGPTKKALKQRFLKLLPCCGPQALPSVSETLAAPASLRPHRPRLLDPDSVDDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTVDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQKDENIMRSMQLFDNVI

PDB Structures

7UKH 7W6S

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

153;155;157;159;164;189;191;193;195;200;237;239;241;248

Disease

Spinocerebellar Ataxia Type 19/22 and Progressive Pseudorheumatoid Dysplasia

Location

Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.

DOI ID

10.1038/35000592; 10.1006/bbrc.2001.4558; 10.1016/s0008-6363(01)00374-1; 10.1074/jbc.m101320200; 10.1016/j.ygeno.2005.07.001; 10.1101/gr.gr1547r; 10.1038/ng1285; 10.1038/nature02462; 10.1101/gr.2596504; 10.1016/s0014-5793(02)03296-9; 10.1074/jbc.m306142200; 10.1016/j.bbrc.2004.07.006; 10.1074/jbc.m311332200; 10.1523/jneurosci.0776-04.2004; 10.1016/s0896-6273(04)00050-9

RefSeq

NP_055406.2 [Q9NS61-6]; NP_775283.1 [Q9NS61-1]; NP_775284.1 [Q9NS61-2]; NP_775285.1 [Q9NS61-7]; NP_775286.1 [Q9NS61-4]; NP_775287.1 [Q9NS61-3]; NP_775289.1 [Q9NS61-9]